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Acquisition of anoikis resistance reveals a synoikis-like survival style in
BEL7402 hepatoma cells. Zhang Z, Cao L, Li J,
Liang X, Liu Y, Liu H, Du J, Qu Z, Cui M, Liu S, Gao L, Ma C, Zhang L, Han
L, Sun W.
Cancer Lett. 2008
Aug 18;267(1):106-15. Epub 2008 Apr 22. Department of Immunology, School of Medicine, Shandong University, Jinan 250012, China. Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and proliferate again under suitable conditions, which indicate a reversible property of these cells. Microarray expression profile reveals the change of molecules involved in the synoikis-like hepatoma cells and our data indicated that ANGPTL4 contributed to anoikis resistance of hepatoma cells. These results demonstrated that hepatoma cells might resist anoikis through a synoikis-like survival style, which may facilitate tumor metastasis. |